Tag: enantioselectivity

BIMP Catalyzed 1,3‐Prototropic Shift for the Highly Enantioselective Synthesis of Conjugated Cyclohexenones.

Golec, J. C.; Carter, E. M.; Ward, J. W.; Whittingham, W. G.; Simón, L.; Paton, R. S.; Dixon, D. J. Angew. Chem. Int. Ed. 2020, 59, 17417–17422

Enantiomerically enriched tetrahydropyridine allyl chlorides.

Karabiyikoglu S. I.; Brethomé, A. V.; Palacin, T.; Paton, R. S.; Fletcher, S. P. Chem. Sci. 2020, 11, 4125-4130

Hydrogen Bonding Phase-Transfer Catalysis with Ionic Reactants: Enantioselective Synthesis of -Fluoroamines.

Roagna, G.; Ascough, D. M. H.; Ibba, F.; Fontana, A.; Christensen, K. E.; Misale, A.; Trabanco, A. A.; Paton, R. S.; Pupo, G.; Gouverneur. V. J. Am. Chem. Soc. 2020, 142, 14045–14051

Enantioselective Rhodium-Catalysed Insertion of Trifluorodiazoethanes into Tin Hydrides.

Hyde, S.; Veliks, J.; Ascough, D. M. H.; Szpera, R.; Paton, R. S.; Gouverneur, V. Tetrahedron (invited contribution) 2019, 75, 17-25

Frontier Molecular Orbital Effects Control the Hole-Catalyzed Racemization of Atropisomeric Biaryls.

Tan, J.; Paton, R. S. Chem. Sci. 2019, 10, 2285-2289

Hydrogen Bond Enabled Dynamic Kinetic Resolution of Axially Chiral Amides Mediated by a Chiral Counterion.

Fugard, A.; Lahdenperä, A.; Mekareeya, A.; Tan, J.; Paton, R. S.; Smith, M. D. Angew. Chem. Int. Ed. 2019, 58, 2795-2798

Hydrogen Bonding Phase-Transfer Catalysis with Potassium Fluoride: Enantioselective Synthesis of Beta-Fluoroamines.

Hydrogen Bonding Phase-Transfer Catalysis with Potassium Fluoride: Enantioselective Synthesis of Beta-Fluoroamines. Pupo, G.; Vicini, A. C. Ascough, D. M. H.; Ibba, F.; Christensen, K. E.; Thompson, A. L.; Brown, J. M.; Paton, R. S.; Gouverneur, V. J. Am. Chem. Soc. 2019, 141, 2878–2883

Retooling Asymmetric Conjugate Additions for Sterically Demanding Substrates with an Iterative Data-Driven Approach.

Brethomé, A. V.; Paton, R. S.; Fletcher, S. P. ACS Catal. 2019, 9, 7179–7187

Asymmetric Nucleophilic Fluorination Under Hydrogen Bonding Phase Transfer Catalysis.

Pupo, G.; Ibba, F.; Ascough, D. M. H.; Vicini, A. C.; Ricci, P.; Christensen, K.; Morphy, J. R.; Brown, J. M.; Paton, R. S.; Gouverneur, V. Science 2018, 360, 638–642

Bifunctional Iminophosphorane Catalysed Enantioselective Sulfa-Michael Addition of Alkyl Thiols to Alkenyl Benzimidazoles.

Formica, M.; Sorin, G.; Farley, A. J. M.; Diaz, J.; Paton, R. S.; Dixon, D. J. Chem. Sci. 2018, 9, 6969–6974

Catalytic Enantio‐and Diastereoselective Mannich Addition of TosMIC To Ketimines.

Franchino, A. Chapman, J.; Funes-Ardoiz, I.; Paton, R. S.; Dixon, D. J. Chem. Eur. J. 2018, 24, 17660–17664

Formation of quaternary centres by copper catalysed asymmetric conjugate addition to β-substituted cyclopentenones with the aid of a quantitative structure–selectivity relationship.

Ardkhean, R.; Mortimore, M.; Paton, R. S.; Fletcher. S. P. Chem. Sci. 2018, 9, 2628–2632

Selectivity in Transition Metal-Catalyzed Cyclizations: Insights from Experiment and Theory.

Anderson, E. A.; Paton, R. S. CHIMIA 2018, 72, 614–620

Stereospecific 1,3-H Transfer of Indenols Proceeds Via Persistent Ion-Pairs Anchored by NH−Pi Interactions.

Ascough, D. M. H.; Duarte, F.; Paton, R. S. J. Am. Chem. Soc. 2018, 140, 16740–16748

The True Catalyst Revealed: the Intervention of Chiral Ca and Mg Phosphates in Brønsted Acid Promoted Asymmetric Mannich Reactions.

Simón, L.; Paton, R. S. J. Am. Chem. Soc. 2018, 140, 5412–5420

Asymmetric Induction in C-Alkylation of Tropane-Derived Enamines: Congruence Between Computation and Experiment.

Li, Y.; Jackson, K. E.; Charlton, A.; Le Neve-Foster, B.; Khurshid, A.; Rudy, H.-K. A.; Thompson, A. L.; Paton, R. S.; Hodgson, D. M. J. Org. Chem. 2017, 82, 10479–10488

Enantioselective Conjugate Addition Catalyzed by a Copper-Phosphoramidite Complex: Computational and Experimental Exploration of Asymmetric Induction.

Ardkhean, R.; Roth, P. M. C.; Maksymowicz, R. M.; Curran, A.; Peng, Q.; Paton, R. S.; Fletcher, S. P. ACS Catal. 2017, 7, 6729–6737

Enantioselective Silver and Amine Cocatalyzed Desymmetrizing Cycloisomerization of Alkyne-Linked Cyclohexanones.

Manzano, R.; Datta, S.; Paton, R. S.; Dixon, D. J. Angew. Chem. Int. Ed. 2017, 56, 5834–5838

Phosphazene Catalyzed Addition to Electron-Deficient Alkynes: the Importance of Nonlinear Allenyl Intermediates Upon Stereoselectivity.

Simón, L.; Paton, R. S. J. Org. Chem. 2017, 82, 3855–3863

Total Synthesis of (−)-Himalensine A.

Shi, H.; Michaelides, I.; Darses, B.; Jakubec, P.; Nguyen, Q. N.; Paton, R. S.; Dixon, D. J. J. Am. Chem. Soc. 2017, 139, 17755–17758

Catalytic Control in Cyclizations: from Computational Mechanistic Understanding to Selectivity Prediction.

Peng, Q.; Paton, R. S. Acc. Chem. Res. 2016, 49, 1042–1051

QM/MM study on the enantioselectivity of spiroacetalization catalysed by an imidodiphosphoric acid catalyst: how confinement works.

Simón, L.; Paton, R. S. Org. Biomol. Chem. 2016, 14, 3031–3039

Catalytic Enantioselective Synthesis of Indanes via Cation-Directed 5-Endo-Trig Cyclization.

Johnston, C. P.; Kothari, A.; Sergeieva, T.; Okovytyy, S. I.; Jackson, K. E.; Paton, R. S.; Smith, M. D. Nat. Chem. 2015, 7, 171–177

Computational Ligand Design in Enantio- and Diastereoselective Ynamide [5+2] Cycloisomerizations.

Straker, R.; Peng, Q.; Mekareeya, A.; Paton, R. S.; Anderson, E. A. Nat. Commun. 2015, 7, 10109

Enantioselective Desymmetrization of Prochiral Cyclohexanones via Organocatalytic Intramolecular Michael Additions To A,B-Unsaturated Esters.

Gammack-Yamagata, A. D.; Datta, S.; Jackson, K. E.; Stegbauer, L.; Paton, R. S.; Dixon, D. J. Angew. Chem. Int. Ed. 2015, 127, 4981–4985

Origins of Asymmetric Phosphazene Organocatalysis: Computations Reveal a Common Mechanism for Nitro- and Phospho-Aldol Additions.

Simón, L.; Paton, R. S. J. Org. Chem. 2015, 80, 2756–2766

Dissecting Non-Covalent Interactions In Oxazaborolidinium Catalyzed Cycloadditions of Maleimides.

Paton, R. S. Org. Biomol. Chem. 2014, 12, 1717–1720

C-Alkylation of Chiral Tropane- and Homotropane-Derived Enamines.

Hodgson, D. M.; Charlton, A.; Paton, R. S.; Thompson, A. S. J. Org. Chem. 2013, 8, 1508–1518

Computational Organic Chemistry.

Jackson, K.; Jaffar, S.; Paton, R. S. Annu. Rep. Prog. Chem., Sect. B, 2013, 109, 235–255

Mechanistic Investigations On the Enantioselective Conia-Ene Reaction Catalyzed by Cinchona-Derived Amino Urea Pre-Catalysts and Cu(I).

Sladojevich, F.; Fuentes de Arriba, A. L.; Yang, T.; Ferrali, A.; Paton, R. S.; Dixon, D. J. Chem. Eur. J. 2013, 19, 14286–14295